Try to avoid window seat during winter season, incase window is not getting closed properly then you will have trouble during your journey.
In case your family members have not got adjacent seats during automatic seat assignment then make a humble request to other travellers and try for seat exchange so that all of you can sit together.
In case you want to take a longer break at some bus stop due to natures call then inform the bus conductor about the delay so that he will wait for you.